Drug interactions
Aspirin rectal + Irbesartan
Severity: Moderate
Aspirin rectal and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses can blunt the effect of irbesartan and impair renal function. Risk is higher in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Aspirin rectal and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes angiotensin receptor blockade.
What to do
Limit aspirin dose and duration where possible. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Aspirin rectal with Irbesartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at analgesic doses can blunt the effect of irbesartan and impair renal function. Risk is higher in older, volume-depleted or renally impaired patients.
How serious is the interaction between Aspirin rectal and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit aspirin dose and duration where possible. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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