Drug interactions
Aspirin rectal + Ketoprofen
Severity: Major
Aspirin rectal and Ketoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed, so ketoprofen combination carries added gastrointestinal bleeding risk and possible loss of aspirin's antiplatelet benefit.
What this interaction means in plain words
Aspirin rectal and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive COX inhibition impairs mucosal protection and platelet function; ketoprofen competes with aspirin at COX-1.
What to do
Avoid regular co-use; if aspirin is for cardioprotection, separate dosing from the NSAID or choose a non-NSAID analgesic. Consider gastroprotection if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Aspirin rectal with Ketoprofen?
MediHelp rates the interaction as major. Aspirin rectal and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rectal aspirin is systemically absorbed, so ketoprofen combination carries added gastrointestinal bleeding risk and possible loss of aspirin's antiplatelet benefit.
How serious is the interaction between Aspirin rectal and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular co-use; if aspirin is for cardioprotection, separate dosing from the NSAID or choose a non-NSAID analgesic. Consider gastroprotection if unavoidable.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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