Drug interactions
Aspirin rectal + Pemetrexed
Severity: Moderate
Aspirin rectal and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and, like other NSAIDs, may reduce pemetrexed clearance. This increases the risk of myelosuppression and renal toxicity, especially with reduced renal function.
What this interaction means in plain words
Aspirin rectal and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal elimination of pemetrexed.
What to do
Avoid NSAID dosing around pemetrexed administration where possible; monitor blood counts and creatinine clearance if use is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin rectal and Pemetrexed, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pemetrexed
Frequently asked questions
Can I take Aspirin rectal with Pemetrexed?
MediHelp rates the interaction as moderate. Aspirin rectal and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and, like other NSAIDs, may reduce pemetrexed clearance. This increases the risk of myelosuppression and renal toxicity, especially with reduced renal function.
How serious is the interaction between Aspirin rectal and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAID dosing around pemetrexed administration where possible; monitor blood counts and creatinine clearance if use is required.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
