Drug interactions
Aspirin rectal + Probenecid
Severity: Moderate
Aspirin rectal and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed aspirin competes with probenecid for renal tubular secretion and can blunt its uricosuric effect. Gout control may worsen.
What this interaction means in plain words
Aspirin rectal and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular anion transport antagonizes probenecid's uricosuric action.
What to do
Avoid analgesic-dose aspirin in patients taking probenecid for gout and use another analgesic such as paracetamol. Monitor serum urate if aspirin is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Aspirin rectal with Probenecid?
MediHelp rates the interaction as moderate. Aspirin rectal and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed aspirin competes with probenecid for renal tubular secretion and can blunt its uricosuric effect. Gout control may worsen.
How serious is the interaction between Aspirin rectal and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid analgesic-dose aspirin in patients taking probenecid for gout and use another analgesic such as paracetamol. Monitor serum urate if aspirin is needed.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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