Drug interactions
Aspirin rectal + Tolazamide
Severity: Moderate
Aspirin rectal and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically, and at analgesic or anti-inflammatory doses salicylates can enhance the effect of sulfonylureas and cause hypoglycemia. Low doses are unlikely to matter.
What this interaction means in plain words
Aspirin rectal and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates may displace sulfonylureas from protein binding and have intrinsic glucose-lowering effects.
What to do
Monitor blood glucose when regular doses of rectal aspirin are used. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Aspirin rectal with Tolazamide?
MediHelp rates the interaction as moderate. Aspirin rectal and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically, and at analgesic or anti-inflammatory doses salicylates can enhance the effect of sulfonylureas and cause hypoglycemia. Low doses are unlikely to matter.
How serious is the interaction between Aspirin rectal and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when regular doses of rectal aspirin are used. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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