Drug interactions
Atazanavir + Atenolol-chlorthalidone
Severity: Moderate
Atazanavir and Atenolol-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir prolongs the PR interval, and combining it with atenolol can add to AV conduction delay, bradycardia and hypotension. Atenolol is renally cleared so it is not affected pharmacokinetically.
What this interaction means in plain words
Atazanavir and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Atenolol-chlorthalidone belongs to Cardiovascular.
Why it happens
Additive slowing of AV nodal conduction from atazanavir-induced PR prolongation and beta-blockade.
What to do
Monitor heart rate, blood pressure and ECG, especially PR interval, at initiation. Lower the atenolol dose or choose another agent if significant bradycardia or AV block develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Atenolol-chlorthalidone?
MediHelp rates the interaction as moderate. Atazanavir and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir prolongs the PR interval, and combining it with atenolol can add to AV conduction delay, bradycardia and hypotension. Atenolol is renally cleared so it is not affected pharmacokinetically.
How serious is the interaction between Atazanavir and Atenolol-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially PR interval, at initiation. Lower the atenolol dose or choose another agent if significant bradycardia or AV block develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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