Drug interactions
Atazanavir + Avanafil
Severity: Contraindicated
Atazanavir and Avanafil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual disturbances and priapism.
What this interaction means in plain words
Atazanavir and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Avanafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated avanafil metabolism reduces its clearance.
What to do
Do not use avanafil with atazanavir; choose another PDE5 inhibitor with dose limits or a non-PDE5 option for erectile dysfunction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Avanafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
- Avanafil + Indinavir Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Atazanavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Atazanavir with Avanafil?
MediHelp rates the interaction as contraindicated. Atazanavir and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual disturbances and priapism.
How serious is the interaction between Atazanavir and Avanafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use avanafil with atazanavir; choose another PDE5 inhibitor with dose limits or a non-PDE5 option for erectile dysfunction.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Clarithromycin, Conivaptan. The full list is on the Avanafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
