Drug interactions
Atazanavir + Eletriptan
Severity: Contraindicated
Atazanavir and Eletriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, increasing the risk of vasoconstrictive and other triptan adverse effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors, including HIV protease inhibitors.
What this interaction means in plain words
Atazanavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Eletriptan belongs to Central Nervous System.
Why it happens
Strong inhibition of CYP3A4-mediated first-pass and systemic metabolism of eletriptan.
What to do
Do not give eletriptan within at least 72 hours of atazanavir. Use a triptan not metabolized by CYP3A4, such as rizatriptan or sumatriptan, with attention to its own precautions.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
- Darunavir + Eletriptan Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Atazanavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Atazanavir with Eletriptan?
MediHelp rates the interaction as contraindicated. Atazanavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, increasing the risk of vasoconstrictive and other triptan adverse effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors, including HIV protease inhibitors.
How serious is the interaction between Atazanavir and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan within at least 72 hours of atazanavir. Use a triptan not metabolized by CYP3A4, such as rizatriptan or sumatriptan, with attention to its own precautions.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Ceritinib, Clarithromycin. The full list is on the Eletriptan page.
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