Drug interactions
Atazanavir + Atenolol
Severity: Moderate
Atazanavir and Atenolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir can prolong PR interval, and combined with atenolol it may increase the risk of bradycardia, AV block and hypotension. Atenolol is not significantly metabolized by CYP so the effect is mainly additive.
What this interaction means in plain words
Atazanavir and Atenolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Atenolol belongs to Cardiovascular.
Why it happens
Additive negative dromotropic effects on AV nodal conduction.
What to do
Monitor heart rate, blood pressure and ECG including PR interval, and reduce atenolol dose if conduction abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Atenolol?
MediHelp rates the interaction as moderate. Atazanavir and Atenolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir can prolong PR interval, and combined with atenolol it may increase the risk of bradycardia, AV block and hypotension. Atenolol is not significantly metabolized by CYP so the effect is mainly additive.
How serious is the interaction between Atazanavir and Atenolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG including PR interval, and reduce atenolol dose if conduction abnormalities develop.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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