Drug interactions
Atazanavir + Betaxolol
Severity: Moderate
Atazanavir and Betaxolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir prolongs the PR interval and can cause AV conduction delay. Combined with betaxolol, which slows AV nodal conduction and heart rate, the risk of bradycardia, AV block and hypotension may increase.
What this interaction means in plain words
Atazanavir and Betaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Betaxolol belongs to Cardiovascular.
Why it happens
Additive negative dromotropic and chronotropic effects on the AV node (pharmacodynamic synergism).
What to do
Monitor heart rate, blood pressure and ECG (PR interval) when combining, especially at initiation. Reduce the betaxolol dose if symptomatic bradycardia or conduction delay develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Betaxolol?
MediHelp rates the interaction as moderate. Atazanavir and Betaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir prolongs the PR interval and can cause AV conduction delay. Combined with betaxolol, which slows AV nodal conduction and heart rate, the risk of bradycardia, AV block and hypotension may increase.
How serious is the interaction between Atazanavir and Betaxolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG (PR interval) when combining, especially at initiation. Reduce the betaxolol dose if symptomatic bradycardia or conduction delay develops.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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