Drug interactions
Atazanavir + Carvedilol
Severity: Moderate
Atazanavir and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir can prolong the PR interval, and combined with carvedilol the risk of bradycardia, AV block and hypotension is increased. Atazanavir may also raise carvedilol exposure through enzyme inhibition.
What this interaction means in plain words
Atazanavir and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Carvedilol belongs to Cardiovascular.
Why it happens
Additive effects on AV nodal conduction and possible inhibition of carvedilol metabolism by atazanavir.
What to do
Monitor ECG, heart rate and blood pressure when starting the combination and reduce the carvedilol dose if bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Carvedilol?
MediHelp rates the interaction as moderate. Atazanavir and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir can prolong the PR interval, and combined with carvedilol the risk of bradycardia, AV block and hypotension is increased. Atazanavir may also raise carvedilol exposure through enzyme inhibition.
How serious is the interaction between Atazanavir and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure when starting the combination and reduce the carvedilol dose if bradycardia or conduction delay occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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