Drug interactions
Atazanavir + Dexamethasone-tobramycin
Severity: Moderate
Atazanavir and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can increase systemic dexamethasone exposure, raising the risk of corticosteroid adverse effects. With ophthalmic dexamethasone the systemic exposure is small, though cases of Cushing syndrome have occurred with boosted protease inhibitors and topical steroids.
What this interaction means in plain words
Atazanavir and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 by atazanavir decreases dexamethasone metabolism.
What to do
With systemic dexamethasone, monitor for steroid excess and consider dose reduction. With prolonged topical use, watch for signs of Cushing syndrome or adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Dexamethasone-tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Atazanavir and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can increase systemic dexamethasone exposure, raising the risk of corticosteroid adverse effects. With ophthalmic dexamethasone the systemic exposure is small, though cases of Cushing syndrome have occurred with boosted protease inhibitors and topical steroids.
How serious is the interaction between Atazanavir and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor for steroid excess and consider dose reduction. With prolonged topical use, watch for signs of Cushing syndrome or adrenal suppression.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
