Drug interactions
Atazanavir + Donepezil
Severity: Moderate
Atazanavir and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and may increase donepezil concentrations. This could increase cholinergic effects such as nausea, bradycardia and syncope.
What this interaction means in plain words
Atazanavir and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Donepezil belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism.
What to do
Monitor heart rate and for gastrointestinal and cholinergic adverse effects. Reduce the donepezil dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Donepezil?
MediHelp rates the interaction as moderate. Atazanavir and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a strong CYP3A4 inhibitor and may increase donepezil concentrations. This could increase cholinergic effects such as nausea, bradycardia and syncope.
How serious is the interaction between Atazanavir and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for gastrointestinal and cholinergic adverse effects. Reduce the donepezil dose if these occur.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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