Drug interactions
Atazanavir + Doxorubicin
Severity: Moderate
Atazanavir and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and P-gp, which may increase doxorubicin exposure. This raises the risk of myelosuppression, mucositis and cardiotoxicity.
What this interaction means in plain words
Atazanavir and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Doxorubicin belongs to Oncology.
Why it happens
Atazanavir inhibits CYP3A4 and P-glycoprotein, decreasing doxorubicin clearance.
What to do
Monitor blood counts and cardiac status closely. Consider an alternative antiretroviral with less CYP3A4/P-gp inhibition if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Doxorubicin?
MediHelp rates the interaction as moderate. Atazanavir and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and P-gp, which may increase doxorubicin exposure. This raises the risk of myelosuppression, mucositis and cardiotoxicity.
How serious is the interaction between Atazanavir and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status closely. Consider an alternative antiretroviral with less CYP3A4/P-gp inhibition if toxicity emerges.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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