Drug interactions
Atazanavir + Empagliflozin-linagliptin
Severity: Minor
Atazanavir and Empagliflozin-linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and P-gp and can modestly raise linagliptin exposure, though linagliptin has a wide safety margin. Protease inhibitors may also worsen glycemic control.
What this interaction means in plain words
Atazanavir and Empagliflozin-linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
CYP3A4/P-gp inhibition reduces linagliptin clearance, and protease inhibitors can induce insulin resistance.
What to do
No linagliptin dose adjustment is required; monitor blood glucose during antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Empagliflozin-linagliptin?
MediHelp rates the interaction as minor. Atazanavir and Empagliflozin-linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and P-gp and can modestly raise linagliptin exposure, though linagliptin has a wide safety margin. Protease inhibitors may also worsen glycemic control.
How serious is the interaction between Atazanavir and Empagliflozin-linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose adjustment is required; monitor blood glucose during antiretroviral therapy.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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