Drug interactions
Atazanavir + Ethosuximide
Severity: Moderate
Atazanavir and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethosuximide is partly metabolized by CYP3A4, so a strong inhibitor such as ritonavir-boosted atazanavir may raise its levels. This could increase dose-related adverse effects such as nausea, drowsiness, dizziness and ataxia.
What this interaction means in plain words
Atazanavir and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Ethosuximide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated ethosuximide metabolism by atazanavir.
What to do
Monitor for ethosuximide toxicity and consider checking serum concentrations. Reduce the dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Ethosuximide?
MediHelp rates the interaction as moderate. Atazanavir and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethosuximide is partly metabolized by CYP3A4, so a strong inhibitor such as ritonavir-boosted atazanavir may raise its levels. This could increase dose-related adverse effects such as nausea, drowsiness, dizziness and ataxia.
How serious is the interaction between Atazanavir and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity and consider checking serum concentrations. Reduce the dose if adverse effects appear.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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