Drug interactions
Atazanavir + Fluticasone furoate
Severity: Moderate
Atazanavir and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a strong CYP3A4 inhibitor, can raise systemic fluticasone furoate concentrations. This can cause cortisol suppression and Cushing syndrome, mainly with prolonged use.
What this interaction means in plain words
Atazanavir and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Atazanavir inhibits CYP3A4, reducing first-pass and systemic clearance of fluticasone.
What to do
Monitor for corticosteroid adverse effects and adrenal suppression with long-term use. Consider an alternative corticosteroid such as beclomethasone if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Fluticasone furoate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Fluticasone furoate?
MediHelp rates the interaction as moderate. Atazanavir and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, a strong CYP3A4 inhibitor, can raise systemic fluticasone furoate concentrations. This can cause cortisol suppression and Cushing syndrome, mainly with prolonged use.
How serious is the interaction between Atazanavir and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects and adrenal suppression with long-term use. Consider an alternative corticosteroid such as beclomethasone if prolonged coadministration is needed.
What other medicines interact with Atazanavir?
MediHelp also lists interactions of Atazanavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Atazanavir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
