Drug interactions
Atazanavir + Griseofulvin
Severity: Moderate
Atazanavir and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a CYP3A4 substrate, and enzyme inducers can reduce its concentrations, risking loss of virologic suppression. Griseofulvin is a weak inducer, so the effect is likely modest but matters in HIV therapy.
What this interaction means in plain words
Atazanavir and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Griseofulvin belongs to Anti Fungals.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase atazanavir clearance.
What to do
Monitor HIV viral load, and atazanavir trough concentrations if available, during and after griseofulvin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Griseofulvin?
MediHelp rates the interaction as moderate. Atazanavir and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a CYP3A4 substrate, and enzyme inducers can reduce its concentrations, risking loss of virologic suppression. Griseofulvin is a weak inducer, so the effect is likely modest but matters in HIV therapy.
How serious is the interaction between Atazanavir and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load, and atazanavir trough concentrations if available, during and after griseofulvin therapy.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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