Drug interactions
Atazanavir + Hydrocortisone
Severity: Moderate
Atazanavir and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which can raise systemic hydrocortisone exposure. With prolonged use, this may produce Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Atazanavir and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Hydrocortisone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by atazanavir reduces hydrocortisone metabolism.
What to do
Monitor for corticosteroid excess such as hyperglycaemia, hypertension and Cushingoid features during prolonged use, and consider reducing the hydrocortisone dose. Take care when stopping the steroid because of adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Hydrocortisone?
MediHelp rates the interaction as moderate. Atazanavir and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, which can raise systemic hydrocortisone exposure. With prolonged use, this may produce Cushingoid effects and adrenal suppression.
How serious is the interaction between Atazanavir and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycaemia, hypertension and Cushingoid features during prolonged use, and consider reducing the hydrocortisone dose. Take care when stopping the steroid because of adrenal suppression.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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