Drug interactions
Atazanavir + Insulin aspart
Severity: Moderate
Atazanavir and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, so insulin requirements may rise after atazanavir is started. Atazanavir is considered to have a comparatively smaller metabolic effect than other protease inhibitors, but glucose control can still worsen.
What this interaction means in plain words
Atazanavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Insulin aspart belongs to Endocrine.
Why it happens
Protease inhibitors may impair peripheral insulin sensitivity and glucose uptake, producing pharmacodynamic antagonism of insulin.
What to do
Monitor blood glucose more frequently when atazanavir is started or stopped. Titrate the aspart dose to maintain glycemic targets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Insulin aspart?
MediHelp rates the interaction as moderate. Atazanavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, so insulin requirements may rise after atazanavir is started. Atazanavir is considered to have a comparatively smaller metabolic effect than other protease inhibitors, but glucose control can still worsen.
How serious is the interaction between Atazanavir and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when atazanavir is started or stopped. Titrate the aspart dose to maintain glycemic targets.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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