Drug interactions
Atazanavir + Lamotrigine
Severity: Moderate
Atazanavir and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted atazanavir lowers lamotrigine concentrations, which may reduce seizure or mood-episode control. Unboosted atazanavir has little effect.
What this interaction means in plain words
Atazanavir and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Lamotrigine belongs to Central Nervous System.
Why it happens
Ritonavir induces lamotrigine glucuronidation (UGT1A4), increasing its clearance.
What to do
With boosted atazanavir, monitor lamotrigine response or serum levels and increase the lamotrigine dose if needed. Reassess the dose when the antiretroviral is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Lamotrigine?
MediHelp rates the interaction as moderate. Atazanavir and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted atazanavir lowers lamotrigine concentrations, which may reduce seizure or mood-episode control. Unboosted atazanavir has little effect.
How serious is the interaction between Atazanavir and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With boosted atazanavir, monitor lamotrigine response or serum levels and increase the lamotrigine dose if needed. Reassess the dose when the antiretroviral is stopped.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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