Drug interactions
Atazanavir + Metronidazole
Severity: Minor
Atazanavir and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a CYP3A4 substrate, but it is usually boosted with ritonavir or cobicistat, which dominate its pharmacokinetics. Metronidazole's weak CYP3A4 effect is unlikely to change atazanavir exposure meaningfully.
What this interaction means in plain words
Atazanavir and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4-mediated atazanavir metabolism.
What to do
No adjustment is required; monitor for atazanavir adverse effects such as hyperbilirubinemia and PR prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Metronidazole?
MediHelp rates the interaction as minor. Atazanavir and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir is a CYP3A4 substrate, but it is usually boosted with ritonavir or cobicistat, which dominate its pharmacokinetics. Metronidazole's weak CYP3A4 effect is unlikely to change atazanavir exposure meaningfully.
How serious is the interaction between Atazanavir and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; monitor for atazanavir adverse effects such as hyperbilirubinemia and PR prolongation.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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