Drug interactions
Atazanavir + Pitavastatin
Severity: Moderate
Atazanavir and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir has produced only small increases in pitavastatin exposure, and it is not labeled as contraindicated with pitavastatin. Modest increases in statin concentration could raise myopathy risk slightly.
What this interaction means in plain words
Atazanavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
Why it happens
Probable weak inhibition of OATP-mediated hepatic uptake and glucuronidation of pitavastatin; the mechanism is not fully established.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Check CK if myalgia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Pitavastatin?
MediHelp rates the interaction as moderate. Atazanavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir has produced only small increases in pitavastatin exposure, and it is not labeled as contraindicated with pitavastatin. Modest increases in statin concentration could raise myopathy risk slightly.
How serious is the interaction between Atazanavir and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Check CK if myalgia develops.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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