Drug interactions
Atazanavir + Tenofovir disoproxil
Severity: Moderate
Atazanavir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil lowers atazanavir exposure, which can reduce antiviral efficacy if atazanavir is unboosted. Atazanavir may also raise tenofovir concentrations, increasing the potential for renal adverse effects.
What this interaction means in plain words
Atazanavir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir lowers atazanavir concentrations by an unclear mechanism, while atazanavir may increase tenofovir exposure.
What to do
Give atazanavir only with ritonavir (300/100 mg) when combined with tenofovir; do not use unboosted atazanavir. Monitor renal function and viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Atazanavir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil lowers atazanavir exposure, which can reduce antiviral efficacy if atazanavir is unboosted. Atazanavir may also raise tenofovir concentrations, increasing the potential for renal adverse effects.
How serious is the interaction between Atazanavir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir only with ritonavir (300/100 mg) when combined with tenofovir; do not use unboosted atazanavir. Monitor renal function and viral load.
What other medicines interact with Atazanavir?
MediHelp also lists interactions of Atazanavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Atazanavir page.
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