Drug interactions
Atazanavir + Zolpidem
Severity: Minor
Atazanavir and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which is one of several pathways that clear zolpidem, so zolpidem exposure may rise modestly. This could increase next-day sedation or psychomotor impairment.
What this interaction means in plain words
Atazanavir and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by atazanavir.
What to do
Start with the lowest zolpidem dose and counsel the patient about next-day drowsiness. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Zolpidem?
MediHelp rates the interaction as minor. Atazanavir and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4, which is one of several pathways that clear zolpidem, so zolpidem exposure may rise modestly. This could increase next-day sedation or psychomotor impairment.
How serious is the interaction between Atazanavir and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zolpidem dose and counsel the patient about next-day drowsiness. Reduce the dose if excessive sedation occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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