Drug interactions
Atenolol + Candesartan-hydrochlorothiazide
Severity: Moderate
Atenolol and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with an ARB and a thiazide is a common and often intended antihypertensive regimen, but it can produce additive hypotension and bradycardia. Beta-blockers can raise potassium slightly and may mask hypoglycemia, while thiazides can worsen glucose tolerance.
What this interaction means in plain words
Atenolol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through different pathways, with minor effects of beta-blockade on potassium shifts.
What to do
Monitor blood pressure, heart rate, potassium and glucose when starting or adjusting therapy. Avoid use in pregnancy because of the ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Atenolol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a beta-blocker with an ARB and a thiazide is a common and often intended antihypertensive regimen, but it can produce additive hypotension and bradycardia. Beta-blockers can raise potassium slightly and may mask hypoglycemia, while thiazides can worsen glucose tolerance.
How serious is the interaction between Atenolol and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, potassium and glucose when starting or adjusting therapy. Avoid use in pregnancy because of the ARB.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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