Drug interactions
Atenolol + Celecoxib
Severity: Moderate
Atenolol and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs including celecoxib can blunt the antihypertensive effect of beta-blockers such as atenolol, particularly with sustained use, leading to higher blood pressure.
What this interaction means in plain words
Atenolol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandins and sodium and water retention counteract beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when starting or stopping celecoxib and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Celecoxib?
MediHelp rates the interaction as moderate. Atenolol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs including celecoxib can blunt the antihypertensive effect of beta-blockers such as atenolol, particularly with sustained use, leading to higher blood pressure.
How serious is the interaction between Atenolol and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping celecoxib and adjust antihypertensive therapy if needed.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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