Drug interactions
Atenolol + Enalapril-hydrochlorothiazide
Severity: Minor
Atenolol and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers and ACE inhibitor/thiazide combinations are commonly used together, with additive blood pressure lowering. Thiazides may modestly worsen glucose tolerance and mask hypoglycemia symptoms when beta-blockers are used in diabetics. Beta-blockers can modestly raise potassium.
What this interaction means in plain words
Atenolol and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, and beta-blockade modestly impairs cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and potassium when initiating combined therapy. Be alert to dizziness in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Atenolol and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers and ACE inhibitor/thiazide combinations are commonly used together, with additive blood pressure lowering. Thiazides may modestly worsen glucose tolerance and mask hypoglycemia symptoms when beta-blockers are used in diabetics. Beta-blockers can modestly raise potassium.
How serious is the interaction between Atenolol and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when initiating combined therapy. Be alert to dizziness in older patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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