Drug interactions
Atenolol + Fosinopril-hydrochlorothiazide
Severity: Moderate
Atenolol and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol and fosinopril-hydrochlorothiazide are often combined for hypertension and produce additive blood pressure lowering. Excessive hypotension or bradycardia can occur, and beta-blockers may modestly raise potassium while thiazides lower it. Thiazides may also worsen glucose tolerance and mask hypoglycemia symptoms with beta-blockers.
What this interaction means in plain words
Atenolol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure, heart rate and serum potassium, especially during initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Atenolol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atenolol and fosinopril-hydrochlorothiazide are often combined for hypertension and produce additive blood pressure lowering. Excessive hypotension or bradycardia can occur, and beta-blockers may modestly raise potassium while thiazides lower it. Thiazides may also worsen glucose tolerance and mask hypoglycemia symptoms with beta-blockers.
How serious is the interaction between Atenolol and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, especially during initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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