Drug interactions
Atenolol + Hydrochlorothiazide-losartan
Severity: Minor
Atenolol and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol and the losartan/hydrochlorothiazide combination are often used together and produce additive blood pressure lowering. Thiazides can raise glucose and may blunt beta-blocker awareness of hypoglycemia, and beta-blockers can modestly raise potassium while losartan retains it. The combination is generally acceptable but needs monitoring.
What this interaction means in plain words
Atenolol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with opposing small effects on serum potassium.
What to do
Monitor blood pressure, heart rate and serum potassium, particularly at initiation and in renal impairment. Watch glucose in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol and Hydrochlorothiazide-losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Atenolol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atenolol and the losartan/hydrochlorothiazide combination are often used together and produce additive blood pressure lowering. Thiazides can raise glucose and may blunt beta-blocker awareness of hypoglycemia, and beta-blockers can modestly raise potassium while losartan retains it. The combination is generally acceptable but needs monitoring.
How serious is the interaction between Atenolol and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, particularly at initiation and in renal impairment. Watch glucose in diabetic patients.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
