Drug interactions
Atenolol + Metoprolol
Severity: Major
Atenolol and Metoprolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are cardioselective beta blockers, so combining them is duplication of therapy. It adds the risk of bradycardia, hypotension and AV block with no extra benefit.
What this interaction means in plain words
Atenolol and Metoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic beta-1 adrenergic blockade.
What to do
Avoid concurrent use and use a single beta blocker at an optimized dose. Monitor heart rate and blood pressure during any transition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Betaxolol + Metoprolol Major
- Bisoprolol + Metoprolol Major
Frequently asked questions
Can I take Atenolol with Metoprolol?
MediHelp rates the interaction as major. Atenolol and Metoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are cardioselective beta blockers, so combining them is duplication of therapy. It adds the risk of bradycardia, hypotension and AV block with no extra benefit.
How serious is the interaction between Atenolol and Metoprolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use a single beta blocker at an optimized dose. Monitor heart rate and blood pressure during any transition.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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