Drug interactions
Betaxolol + Metoprolol
Severity: Major
Betaxolol and Metoprolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta1-selective blockers, so combining them duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Ophthalmic betaxolol may also contribute systemically.
What this interaction means in plain words
Betaxolol and Metoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betaxolol belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive beta1-adrenergic receptor blockade.
What to do
Avoid concurrent use and keep one beta-blocker. If both are taken, stop one and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Bisoprolol + Metoprolol Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Metoprolol?
MediHelp rates the interaction as major. Betaxolol and Metoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are beta1-selective blockers, so combining them duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Ophthalmic betaxolol may also contribute systemically.
How serious is the interaction between Betaxolol and Metoprolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep one beta-blocker. If both are taken, stop one and monitor heart rate and blood pressure.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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