Drug interactions
Atenolol + Sulindac
Severity: Moderate
Atenolol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac can blunt the blood pressure lowering effect of beta-blockers, especially with continued use over more than a week. Blood pressure control may deteriorate in hypertensive patients.
What this interaction means in plain words
Atenolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory renal and vascular prostaglandins by sulindac causes sodium and fluid retention, opposing the antihypertensive effect.
What to do
Monitor blood pressure when starting or stopping the NSAID and adjust the antihypertensive dose if needed. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Sulindac?
MediHelp rates the interaction as moderate. Atenolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac can blunt the blood pressure lowering effect of beta-blockers, especially with continued use over more than a week. Blood pressure control may deteriorate in hypertensive patients.
How serious is the interaction between Atenolol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID and adjust the antihypertensive dose if needed. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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