Drug interactions
Atenolol + Treprostinil
Severity: Moderate
Atenolol and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with a beta-blocker such as atenolol can produce additive blood pressure lowering. Symptomatic hypotension may occur, particularly after dose initiation or titration.
What this interaction means in plain words
Atenolol and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effect from prostacyclin-mediated vasodilation and beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting treprostinil. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol and Treprostinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Atenolol with Treprostinil?
MediHelp rates the interaction as moderate. Atenolol and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with a beta-blocker such as atenolol can produce additive blood pressure lowering. Symptomatic hypotension may occur, particularly after dose initiation or titration.
How serious is the interaction between Atenolol and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting treprostinil. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
