Drug interactions
atenolol + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Risk of significant bradycardia, AV block, hypotension, and acute decompensated heart failure with combined non-DHP CCB and beta-blocker therapy.
Mechanism of action
Additive negative chronotropic, dromotropic, and inotropic effects on the AV node and myocardium.
Clinical management
Avoid combination when possible. If necessary, use lowest effective doses, avoid IV coadministration, and closely monitor HR, BP, ECG (PR interval) and heart failure symptoms.
Drug reference
References
- Verapamil Hydrochloride Prescribing Information — Warnings: Concomitant Use with Beta-Blockers — FDA Label
- Verapamil: Drug Interactions — Lexicomp
- Calcium channel blockers: Drug interactions — UpToDate
Frequently asked questions
Can I take atenolol with verapamil?
The interaction is rated: Major. Risk of significant bradycardia, AV block, hypotension, and acute decompensated heart failure with combined non-DHP CCB and beta-blocker therapy.
How serious is the interaction between atenolol and verapamil?
The interaction is rated: Major. Evidence level: High.
How is the interaction between atenolol and verapamil managed?
Avoid combination when possible. If necessary, use lowest effective doses, avoid IV coadministration, and closely monitor HR, BP, ECG (PR interval) and heart failure symptoms.
Why do atenolol and verapamil interact?
Additive negative chronotropic, dromotropic, and inotropic effects on the AV node and myocardium.
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