Drug interactions
Atenolol-chlorthalidone + Benazepril
Severity: Moderate
Atenolol-chlorthalidone and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors combined with diuretics and beta-blockers produce additive blood pressure lowering, and first-dose hypotension may occur in volume-depleted patients. Renal function and potassium may also change, particularly with dehydration.
What this interaction means in plain words
Atenolol-chlorthalidone and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with diuretic volume depletion enhancing ACE inhibitor hypotension and renal effects.
What to do
Monitor blood pressure, serum creatinine and electrolytes after initiation or dose changes, and consider reducing diuretic dose before starting benazepril.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Benazepril?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors combined with diuretics and beta-blockers produce additive blood pressure lowering, and first-dose hypotension may occur in volume-depleted patients. Renal function and potassium may also change, particularly with dehydration.
How serious is the interaction between Atenolol-chlorthalidone and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and electrolytes after initiation or dose changes, and consider reducing diuretic dose before starting benazepril.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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