Drug interactions
Atenolol-chlorthalidone + Chlorothiazide
Severity: Moderate
Atenolol-chlorthalidone and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is a thiazide diuretic, so giving it with chlorthalidone duplicates diuretic therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension.
What this interaction means in plain words
Atenolol-chlorthalidone and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive inhibition of sodium-chloride reabsorption in the distal tubule leads to enhanced urinary loss of potassium, sodium and magnesium.
What to do
Avoid therapeutic duplication unless sequential nephron blockade is deliberate; if used, monitor electrolytes and renal function within the first weeks and adjust doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Atenolol-chlorthalidone with Chlorothiazide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide is a thiazide diuretic, so giving it with chlorthalidone duplicates diuretic therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension.
How serious is the interaction between Atenolol-chlorthalidone and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication unless sequential nephron blockade is deliberate; if used, monitor electrolytes and renal function within the first weeks and adjust doses.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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