Drug interactions
Atenolol-chlorthalidone + Diazoxide
Severity: Moderate
Atenolol-chlorthalidone and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both diazoxide and thiazide diuretics can raise blood glucose, and diazoxide is chemically related to thiazides. Combined use may produce additive hyperglycemia, as well as hyperuricemia and additive hypotension.
What this interaction means in plain words
Atenolol-chlorthalidone and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive suppression of insulin secretion by diazoxide and thiazide-type diuretics.
What to do
Monitor blood glucose and uric acid and adjust antidiabetic therapy as needed. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Diazoxide
Frequently asked questions
Can I take Atenolol-chlorthalidone with Diazoxide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both diazoxide and thiazide diuretics can raise blood glucose, and diazoxide is chemically related to thiazides. Combined use may produce additive hyperglycemia, as well as hyperuricemia and additive hypotension.
How serious is the interaction between Atenolol-chlorthalidone and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and uric acid and adjust antidiabetic therapy as needed. Monitor blood pressure.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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