Drug interactions
Diazoxide + Glyburide-metformin
Severity: Major
Diazoxide and Glyburide-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide suppresses insulin release and causes hyperglycemia, directly opposing glyburide-metformin. Glycemic control can deteriorate markedly.
What this interaction means in plain words
Diazoxide and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazoxide belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic KATP channels, inhibiting insulin secretion, which counters the sulfonylurea.
What to do
Avoid the combination if possible; if used, monitor blood glucose closely and increase antidiabetic therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Glyburide-metformin?
MediHelp rates the interaction as major. Diazoxide and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diazoxide suppresses insulin release and causes hyperglycemia, directly opposing glyburide-metformin. Glycemic control can deteriorate markedly.
How serious is the interaction between Diazoxide and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor blood glucose closely and increase antidiabetic therapy.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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