Drug interactions
Diazoxide + Insulin degludec-insulin aspart
Severity: Major
Diazoxide and Insulin degludec-insulin aspart: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral diazoxide causes hyperglycemia and directly opposes insulin, so diabetic patients may lose glycemic control and need substantially higher insulin doses.
What this interaction means in plain words
Diazoxide and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazoxide belongs to Miscellaneous; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic beta-cell potassium-ATP channels, inhibiting insulin secretion, and also increases catecholamine release and reduces peripheral glucose uptake.
What to do
Avoid the combination where possible; if used, monitor glucose frequently and titrate insulin upward, watching for hypoglycemia when diazoxide is withdrawn.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
- Insulin degludec-insulin aspart + Pramlintide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as major. Diazoxide and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral diazoxide causes hyperglycemia and directly opposes insulin, so diabetic patients may lose glycemic control and need substantially higher insulin doses.
How serious is the interaction between Diazoxide and Insulin degludec-insulin aspart?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor glucose frequently and titrate insulin upward, watching for hypoglycemia when diazoxide is withdrawn.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Ethanol. The full list is on the Insulin degludec-insulin aspart page.
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