Drug interactions
Atenolol-chlorthalidone + Diflunisal
Severity: Moderate
Atenolol-chlorthalidone and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal, like other NSAIDs, can reduce the blood pressure lowering effect of atenolol and chlorthalidone. It may also contribute to fluid retention and reduced renal function in patients taking diuretics.
What this interaction means in plain words
Atenolol-chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention and counteracts antihypertensive effects.
What to do
Monitor blood pressure and renal function with prolonged use. Prefer paracetamol or the shortest NSAID course where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Diflunisal?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal, like other NSAIDs, can reduce the blood pressure lowering effect of atenolol and chlorthalidone. It may also contribute to fluid retention and reduced renal function in patients taking diuretics.
How serious is the interaction between Atenolol-chlorthalidone and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function with prolonged use. Prefer paracetamol or the shortest NSAID course where possible.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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