Drug interactions
Atenolol-chlorthalidone + Etodolac
Severity: Moderate
Atenolol-chlorthalidone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the antihypertensive and diuretic effects of atenolol and chlorthalidone. NSAID use with diuretics also raises the risk of renal impairment.
What this interaction means in plain words
Atenolol-chlorthalidone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure and renal function if NSAID therapy continues beyond a short course. Use the lowest effective dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Etodolac?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the antihypertensive and diuretic effects of atenolol and chlorthalidone. NSAID use with diuretics also raises the risk of renal impairment.
How serious is the interaction between Atenolol-chlorthalidone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if NSAID therapy continues beyond a short course. Use the lowest effective dose or an alternative analgesic.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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