Drug interactions
Atenolol-chlorthalidone + Folic acid
Severity: Minor
Atenolol-chlorthalidone and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly increase urinary folate loss, but clinically significant folate deficiency from this is uncommon. The evidence is limited and no routine supplementation is required.
What this interaction means in plain words
Atenolol-chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol-chlorthalidone belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Possible increased renal folate clearance, which is not well established.
What to do
No action is needed unless the patient has other risk factors for folate deficiency; check folate status if anemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Folic acid?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly increase urinary folate loss, but clinically significant folate deficiency from this is uncommon. The evidence is limited and no routine supplementation is required.
How serious is the interaction between Atenolol-chlorthalidone and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed unless the patient has other risk factors for folate deficiency; check folate status if anemia occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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