Drug interactions
Atenolol-chlorthalidone + Irbesartan
Severity: Moderate
Atenolol-chlorthalidone and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan adds blood pressure lowering to atenolol-chlorthalidone, and first-dose hypotension may occur in volume-depleted patients. Irbesartan can offset chlorthalidone-induced potassium loss but may also raise potassium in some patients, and renal function can change.
What this interaction means in plain words
Atenolol-chlorthalidone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with angiotensin receptor blockade reducing aldosterone-mediated potassium excretion opposite to the diuretic.
What to do
Monitor blood pressure, potassium and creatinine after starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Irbesartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan adds blood pressure lowering to atenolol-chlorthalidone, and first-dose hypotension may occur in volume-depleted patients. Irbesartan can offset chlorthalidone-induced potassium loss but may also raise potassium in some patients, and renal function can change.
How serious is the interaction between Atenolol-chlorthalidone and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and creatinine after starting or changing doses. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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