Drug interactions
Atenolol-chlorthalidone + Ketoprofen
Severity: Moderate
Atenolol-chlorthalidone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ketoprofen can reduce the antihypertensive effect of beta-blockers and thiazide-type diuretics. They may also reduce renal function and raise the risk of acute kidney injury, particularly in older or volume-depleted patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces the blood pressure-lowering and diuretic effects.
What to do
Monitor blood pressure and renal function if the NSAID is used beyond a few days. Use the lowest effective NSAID dose for the shortest time or consider paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Ketoprofen?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ketoprofen can reduce the antihypertensive effect of beta-blockers and thiazide-type diuretics. They may also reduce renal function and raise the risk of acute kidney injury, particularly in older or volume-depleted patients.
How serious is the interaction between Atenolol-chlorthalidone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if the NSAID is used beyond a few days. Use the lowest effective NSAID dose for the shortest time or consider paracetamol.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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