Drug interactions
Atenolol-chlorthalidone + Pilocarpine
Severity: Moderate
Atenolol-chlorthalidone and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist that can slow cardiac conduction, and combined with atenolol it may cause bradycardia or conduction disturbances. Systemic pilocarpine labeling advises caution with beta-blockers for this reason.
What this interaction means in plain words
Atenolol-chlorthalidone and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive effects on cardiac conduction from muscarinic stimulation and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease when oral pilocarpine is used, and reduce or stop it if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
- Bisoprolol + Pilocarpine Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Pilocarpine?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist that can slow cardiac conduction, and combined with atenolol it may cause bradycardia or conduction disturbances. Systemic pilocarpine labeling advises caution with beta-blockers for this reason.
How serious is the interaction between Atenolol-chlorthalidone and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease when oral pilocarpine is used, and reduce or stop it if symptomatic bradycardia occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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