Drug interactions
Bisoprolol + Pilocarpine
Severity: Moderate
Bisoprolol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral pilocarpine has systemic cholinergic effects and may affect cardiac conduction, and beta-blockers can add to this. Bradycardia or conduction disturbances are possible.
What this interaction means in plain words
Bisoprolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive effects on cardiac conduction from muscarinic agonism and beta-1 blockade.
What to do
Monitor pulse and blood pressure when oral pilocarpine is started. Reduce or stop pilocarpine if symptomatic bradycardia or conduction block develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Bisoprolol with Pilocarpine?
MediHelp rates the interaction as moderate. Bisoprolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral pilocarpine has systemic cholinergic effects and may affect cardiac conduction, and beta-blockers can add to this. Bradycardia or conduction disturbances are possible.
How serious is the interaction between Bisoprolol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure when oral pilocarpine is started. Reduce or stop pilocarpine if symptomatic bradycardia or conduction block develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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