Drug interactions
Atenolol-chlorthalidone + Probenecid
Severity: Moderate
Atenolol-chlorthalidone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone raises serum uric acid and can blunt the uricosuric effect of probenecid, which is used to lower urate. Thiazide-type diuretics and probenecid also compete for renal tubular organic anion secretion, so exposure to either can change.
What this interaction means in plain words
Atenolol-chlorthalidone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-induced urate retention and competition for renal tubular organic anion transport.
What to do
Monitor serum uric acid and gout control, and increase the probenecid dose if urate targets are not met. Consider a different antihypertensive if gout control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Probenecid?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone raises serum uric acid and can blunt the uricosuric effect of probenecid, which is used to lower urate. Thiazide-type diuretics and probenecid also compete for renal tubular organic anion secretion, so exposure to either can change.
How serious is the interaction between Atenolol-chlorthalidone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and increase the probenecid dose if urate targets are not met. Consider a different antihypertensive if gout control is poor.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
