Drug interactions
Atenolol-chlorthalidone + Sulindac
Severity: Moderate
Atenolol-chlorthalidone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac can blunt the antihypertensive effect of beta-blockers and diuretics through prostaglandin inhibition and sodium and water retention. They can also impair renal function, particularly in volume-depleted patients taking diuretics, though sulindac has somewhat less renal prostaglandin effect than other NSAIDs.
What this interaction means in plain words
Atenolol-chlorthalidone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Inhibition of prostaglandin synthesis causing sodium and fluid retention and reduced renal perfusion, opposing antihypertensive and diuretic effects.
What to do
Monitor blood pressure and renal function when sulindac is used for more than a few days. Use the lowest effective NSAID dose for the shortest time or consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Sulindac?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac can blunt the antihypertensive effect of beta-blockers and diuretics through prostaglandin inhibition and sodium and water retention. They can also impair renal function, particularly in volume-depleted patients taking diuretics, though sulindac has somewhat less renal prostaglandin effect than other NSAIDs.
How serious is the interaction between Atenolol-chlorthalidone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when sulindac is used for more than a few days. Use the lowest effective NSAID dose for the shortest time or consider an alternative analgesic.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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