Drug interactions
Atenolol-chlorthalidone + Tolazamide
Severity: Moderate
Atenolol-chlorthalidone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and reduce the effect of sulfonylureas such as tolazamide. In addition, atenolol may mask adrenergic warning symptoms of hypoglycemia and can prolong recovery from it.
What this interaction means in plain words
Atenolol-chlorthalidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia (potassium depletion, reduced insulin release, insulin resistance) opposes sulfonylurea action, while beta-blockade blunts hypoglycemia awareness.
What to do
Monitor blood glucose and HbA1c after starting or changing the combination and adjust the tolazamide dose as needed. Educate the patient that sweating is preserved but tremor and palpitations may be masked during hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Tolazamide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise blood glucose and reduce the effect of sulfonylureas such as tolazamide. In addition, atenolol may mask adrenergic warning symptoms of hypoglycemia and can prolong recovery from it.
How serious is the interaction between Atenolol-chlorthalidone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the combination and adjust the tolazamide dose as needed. Educate the patient that sweating is preserved but tremor and palpitations may be masked during hypoglycemia.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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